O Prof. Nicolas Bertrand (website), pesquisador da Laval University do Canada, discute no "Café com Ciência" como modificações (superficiais) em nanopartículas poliméricas afetam a interação com sistema imunológico inato e adaptativo.
Polymer nanoparticles to study the interactions between nanomedicines and the immune system
Palestrante: Prof. Dr. Nicolas Bertrand
Afiliação: Faculty of Pharmacy – CHU de Quebec Research Center, Laval University, Quebec City, QC, Canada
Data: 03/09/2018 (segunda-feira)
Local: Anfiteatro I do IF/UFG.
The architecture of nanoparticles governs how they are perceived by the host upon administration. To develop efficient nanomedicines, the mechanisms regulating blood circulation and clearance need to be understood. In this work, we will visit how libraries of nanoparticles can be used to study the impact of the innate and adaptive immune systems on the clearance of drug delivery systems, after one multiple injections.
Our laboratory studies liposomes and nanoparticles prepared from poly(ethylene glycol)-b-poly(lactic-co-glycolic acid) (PEG-PLGA)copolymers. Using pharmacokinetic and biodistribution in mice and rats, we try to understand how interrelationships between circulatory, metabolic and immune systems dictate the biological fate of nanoparticles. Comparing systems with a broad range of physicochemical properties, we believe we can find structure-activity relationships that help building better performing technologies.